Happy Belated New Year

Hello Everyone,

I’ve been taking some time off from updating to prepare for a few upcoming interviews.  I’d like to mention briefly a few things about what’s expected of a scientist applying for a tenure-track faculty positions.

I’m taking my idea of “Molecular Yoga” on the road and it’s going to influence the first part of my presentation: my “Job Talk”.  Most positions expect you to give them a brief overview of your research interests in an initial Skype interview before they invite you to their campus.  The Job Talk is where I get to tell my story and describe the research goals for my lab.  It has to be both compelling and reasonable; finding the perfect balance is the challenge.  I promise to elaborate more on some of the successes and failures of my job talks in the future once I have some experience!

The second portion of the interview is usually a short teaching tutorial.  I’ve been asked to prepare lectures for specific topics.  I believe a key component here is to demonstrate my ability to 1) analyze a topic that is not directly related to my research, 2) develop learning goals centered on the key components of that topic, and 3) deliver a presentation that helps students achieve those learning goals.  This is, in essence, my chance to prove that I am both a scientist and an educator.  Again I hope to provide a breakdown of what i thought works and does not work as part of an interview in the future.

Thank you all again for reading this quick update.  I’ll be back soon with some more in-depth analysis.




Into the Fray of Faculty Position Hunting

Hello Everyone,

As I mentioned before about a month ago, I’m beginning my search for a faculty position.  This is my first attempt at looking for positions beyond postdocs so I wanted to give a sense of what I’ve learned and what advice I’ve been given up till now.

Where do you learn about faculty positions to apply for in the first place?  There are three main sources I’ve been using at the moment.

  • The first is through direct contacts. I met search committee members through the ACS Academic Employment Initiative in August and I’ve tried to keep in touch with them via Linkedin or direct email.  This, along with recommendations from colleagues, advisors, and personal friends, is probably the best place to start.  As with any job, getting your foot in the door is the first hurdle.
  • The second source I’m using is HigherEdJobs.com and other academic job listing websites. Here you’ll get a list of recent postings by HR departments at various colleges and universities.  This is nice because you know that these departments are actively recruiting a new faculty member and you get an idea of the timeline for hiring.
  • Finally, I’ve been perusing websites of specific departments from Universities at which I would like to be employed. This, I feel, can be the most difficult and possibly soul-crushing way of doing things.  It’s equivalent to a cold-call almost; you don’t even know if a department has an opening.  That being said, I’ve come to understand that the name of the game is “take every opportunity you can find” and these three sources provide opportunities.

Looking glass

What goes into an application for a faculty position in academia?  First up is the curriculum vitae or C.V. for short.  For those readers who are not in academia, a C.V. is similar to a resume but with heavier focus on academic accomplishments and education/teaching history rather than previous jobs.  These are the most crucial components to an academic position, hence why a C.V. is vastly preferred to a resume (something I might tackle in a later article).

All positions will require a cover letter.  This is where I’ve come to understand most people make their mistakes.  DO NOT use the same exact cover letter for each position.  It may seem tedious at first, but this is the first thing, other than the C.V. that a search committee will read.  The cover letter is a chance to make my elevator pitch for a position, I try to specifically bring up reasons for why I am interested in that position. Also, I make sure to specifically mention WHAT I am applying for: e.g. “I am applying for a position in X Department at Y University”.  I’ve heard a possibly apocryphal story where an otherwise spectacular candidate for NASA was rejected initially because their cover letter was addressed to the wrong agency.

The main body of the application is the Teaching Statement and Research Statement.  Here I’m laying out the evidence to show that I can be a successful faculty member in your department.  The Teaching Statement is a brief description of my Teaching Philosophy (how I approach a class), my experiences in teaching, and finally a brief description of classes which I believe I can teach for a specific department.  Again, DO NOT submit the exact same Teaching Statement for each position, especially in regards to the last point.  It makes no sense to be talking about my willingness to teach molecular biology if I’m applying to a mathematics department.  The Research Statement is my description of a few ideas I have for projects and programs in my new lab.  New faculty are always expected to secure “outside funding”, meaning that after a few years my lab work should be bringing in funding to sustain the lab members.  In many ways it’s like getting a start-up fund to start a new company, for good or for bad.  Knowing that search committees will likely go through hundreds of applications I’ve tailored mine to be 3-4 pages with figures and citations.  I hope that I’ve made it an exciting read and after a while I might even share it here as a templet.

The final components of an application for a faculty position in academia are the references and, at some places, a diversity statement.  The references are straight forward, make sure to ask former/current advisors if they could provide a strong recommendation and testament to your ability to work independently in a lab.  The diversity statement I find most interesting.  Some academics might write off a diversity statement as an unimportant, secondary component of an application.  I, however, think it’s a crucial part of explaining that ever-present, “Broader Impact” that we want to get at as scientists.  Diversity means inclusion in the scientific process.  In general I personally often forget that when I’m conducting research, when I’m making devices; this knowledge or these products are going to be used out in the world.  I’m not just doing this for other scientists like myself, I need to understand the communities that are impacted by my research.  I’ve learned this in Public Health, you need to have feedback and communication with people from all over the world.  Insights from as diverse of a group as possible are absolutely crucial.  This is the point that I stress in my diversity statement: I don’t want to make a small, isolated lab kingdom.  Our lab absolutely needs input and collaboration in the communities which its work is meant to serve which is underdeveloped or economically depressed areas.

These are the components of my application.  If anyone has insights to add or advice I would greatly appreciate it!  I hope that in going through this process for the first time I can get a better idea of what I’m doing and that I’ll have better advice to give in the future.  I will keep everyone updated on the results!  Thanks again for reading!



Moving on in Science

Hello Everyone,
For this post I wanted to make a brief comment on something that applies not only to science but also to any job in general: knowing when to move on from a particular position. Change is an inherent part of science. As new ideas come about, it becomes time to build upon them and move forward. Sometimes it’s also good to think about when to move on to the next phase of your career. The most successful scientists that I’ve known are able to adapt to changes. I’ve known people who started out in basic electrochemistry and who are now studying cancer biology. I’m always finding myself reading about new labs and new research and thinking “I wish I was working in this field”. I believe it’s that kind of drive, and that kind of enthusiasm that keeps a scientist alive.

For myself, I know I’ve always had to balance my devoting enough time to a particular project and my search for new projects. As I’ve said before, in getting your science funded even, the old joke is that you write a grant to get money for work you’ve already finished while you’re thinking about the next grant. Like anything there are ebbs and flows in science. Sometimes new data seems to be coming in easily and sometimes a direction I’m moving in just feels static. My advice would be to time the “focusing and dedicating time” in a particular area to the ebbs and to start thinking about new ideas during the flows. If I could possibly do so, let me coin the term “Data Drought” in this particular time. A Data Drought, being a time when you are not producing much, is NOT the time to be thinking about something new. That’s how you lose your focus; that’s the “grass is always greener” mentality. This again is broadly applicable; I’d like to think about why I’m not being productive rather than chalk it up to the field I’m in being dead. Again when times are easy and when you’re really productive: that’s the time to start branching out and to start thinking about moving on.

Personally I’ve always felt that the publication of a paper, the finishing of a dissertation, or the completion of a project is the time to starting thinking about what’s next. For me, I’ve just wrapped up several papers and it’s gotten me thinking about smaller side projects that I could complete while looking towards the next phase of my career. I also know that it’s just the type of person that I am; I can never seem to rest on my laurels. I don’t know if that necessarily makes for a happy life but it makes for a good scientist personality. Right now I’m putting together applications and I’ll be going through the process of looking for faculty positions and/or a second postdoc. I hope to write a post in the near future that compares it to my first experience applying for postdoc positions (and to applying for grad school) to give you some insight into the process. Thanks for reading again!



New Publication: An Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs

Hello Everyone,

I’m excited to announce that our paper finally came out!  This was my first corresponding author paper and also my first decision to publish in an open source journal (meaning you should be able to read it for free).  This work is the culmination of what I’ve been doing for the past 2 years or so at PHRI as an independent researcher.  The patent for it is submitted as well.  Things have changed a lot for me very recently and left me wondering where to go with my career.  I’m considering branching out on my own and sending applications for PI positions to various places.  I’ll keep you all posted on how that process goes as well.






Nature VS Patent Process

Hello Everyone,

I apologize for holding up my writing this month.  I wanted to mention the reason why: it has to do with submitting a patent for one of my projects.  I thought this would be a good opportunity to explain a little bit of the process as I’ve experienced it.  I had what was almost a 3 hour long conversation with our patent lawyer last week and got a few of the insights into the field of patent law and how it relates specifically to biomolecules.  This is the first time I will do this but I feel it needs mentioning: I AM NOT a patent lawyer myself.  Though you may like my opinions expressed on this blog please do not take any of what I say here as legal advice.


Patents have always been, and always will be, a source of contention and defensiveness amongst scientists.  You can look back to famous examples such as the long patent battles between Thomas Edison and Nikola Tesla for one example (1).  Another more recent battle that I’ve brought up before is the fight between The University of California at Berkeley and Harvard University over the rights to CRISPr (2).  But perhaps the oldest opponent bioengineers and biochemists have in patent battles is nature itself.  Our patent lawyer explained to me that the first hurdle to clear in patenting a molecule is determining whether or not it could be considered “A Product of Nature”.  This is to say, to some extent, molecules that exist naturally cannot be patented.  Imagine if someone held a patent on the 20 essential amino acids themselves or on the four nucleic acids that make up our DNA!  In my non-legal opinion it’s completely unfair to allow someone to try to claim a patent on something our bodies make naturally.  The ways to get around this involve, for instance, patenting a process to purify these compounds rather than the compounds themselves.  The main point, however, is that to secure a patent you need to make something new or to find a new way to make something old.  If you can prove you are not cheating nature then you get the Intellectual Property; you get to decide who makes this produce or uses this process

The power of Intellectual Property and Patent Law has driven the field of synthetic biology, Big Pharma, and yes, even my “Molecular Yoga”.  Scripps Research Institute points out, “Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades.” (3). Note their use of the phrase “drugs and drug leads.  A drug lead, or more commonly called a lead compound, is a starting point for biomedical researchers.  These molecules can be altered and changed to improve the drugs by way of increasing the drug’s binding strength or decreasing side-effects (4).  As our patent lawyer pointed out: THAT is what you can patent, as long as you can prove that such changes and alterations were not obvious or already present in small quantities in nature.  This is why pharmaceutical companies are focused on screening or rational design of lead compounds; it makes them more easily patentable.

My job, in helping to craft this patent, is to turn what written for an upcoming paper into a set of claims on the patent.  Part my discussion last week was determining what we felt we could claim related to our molecules.  How, specifically do these molecules work?  How are these molecules made?  What variations, if any, can exist?  Biomolecular patents can have dozens, even hundreds of claims.  The goal is to make a patent as broad as possible such that someone cannot easily infringe upon that patent.  Would-be infringers might take your molecule and alter it in some nominal way and claim it as their own work.  If you can secure a patent with strongly enforceable claims, you can make money off of them through licensing, which will help you fund future research

When I started down the road of becoming a scientist I didn’t make patenting my work one of my main goals.  I wanted to create new molecules, things that were useful, but not necessarily things that would make me money.  In my opinion, patenting your molecules should be a means to an end, a way to sustain your research.  There are a few colleagues of mine who’ve made millions of dollars from patenting simple biomolecules.  I imagine it’s hard to prevent yourself from becoming consumed by the drive to make money over the drive to conduct research.  They seem to be doing well though.  They funnel a lot of that money back into their own lab.  This model works especially well for a soft-money driven research facility based on grant-funded rather than tenured positions (something I’d like to go into at a later date).  I was involved in creating another patent as a graduate student, which was subsequently accepted as a provisional patent.  It appears to me that his work will be heading in that direction as well.  I will keep you up to date with my feelings on patents and hopefully this will serve as a good reminder to myself if my views ever change drastically.

Thanks for reading again!





Reviewer Responsibility

Hello Everyone,

Today I wanted to discuss how we see the responsibility of reviewers in science.  Peer-review is an integral component of the scientific community.  The ability to evaluate and critique the work of others is vitally important in science.  I’ve sort of touched on this before when talking about skepticism in science.  You can think of a scientific article as an argument that someone is presenting.  They need to present the argument as a hypothesis and to defend that hypothesis with their data.  At the same time, those reviewing the argument and the data need to be qualified enough to give an informative critique; they need to be peers.  I’ll describe what I see as the “modern” style of peer review and then move on to what I see as the “new” style.

The “modern” style of peer review as I would call it has been in use since at least the mid-20th century.  Scientific articles had been publish before this time, with editors themselves taking charge of reviewing manuscripts.  In the 1950’s and 1960’s academia had grown to such a point where there was both a demand that colleagues be able to review papers in their field before publication and enough qualified people to efficiently outsource the review process (1).  In this modern review process, the editor sends out the manuscript to individuals in the field.  How these individuals are selected is still somewhat of a mystery to the public at large and, in my opinion, to most of the scientific community as well.  Ideally, the reviewers are other scientists who have worked on the same topic or in the same scientific field.  The reason for this could be twofold.  For one you don’t need to provide as much background information to people already familiar with terms in the article under review, and for two you are much more likely to hold the attention and interests of people who can make connections to their own work.

There is, however, much of the criticism and concern surrounding modern peer-review.  In modern peer-review the article authors are not supposed to know their reviewers.  This sets up the perverse incentive for someone publishing a similar article to attack competing work unfairly or thwart it’s publication for their own interests.  Alternatively, a collaborator might provide very kind review if the paper’s publication might lead to publications for themselves down the line.  Most journals have mechanisms to prevent both of these from happening.  When submitting an article you are allowed to list a few scientists who “you would not like to be considered for review”.  The journal will also mention that you can submit “suggested reviewers” but they cannot be coauthors nor can they be individuals with whom you had professional dealing within the past 4-5 years (e.g. you didn’t write a grant together, you didn’t publish a paper together, you don’t co-advise students etc).  These, of course, are just suggestions.  The editor gets the final say on picking the reviewers, and they could send it to someone who will give a poor review no matter what.  You will not know who the reviewers are during the process and you might never know who reviewed your article.   I feel that this modern peer review style is becoming obsolete and that a new peer-review style is emerging.


There is a new style of peer-review emerging since the beginning of the 21st century: Open Review.  This type of review has been gaining more mainstream acceptance with the rise of Open-access journals and sites like Publons, which track reviews and reviewer records (2).  Under this type of review process everything is out in the open and accessible.  All communications between the reviewers and the authors are known and even the identities of the reviewers are known.  The content of the reviews will be available along with the article if it is accepted for publication.  Additionally there are “post-publication” reviewer, which critique the article after it has been accepted.  The goal of this type of review is to demystify the entire process and to facility better discussion about the scholarly merits of an article.  The downsides are obvious: there is the threat of collusion, but some studies have shown that there is very little difference in the quality of reviews or the outcome when using an open peer review process as opposed to the more traditional process (3).  By opening up the review process we can make the scientific merit of an article stand out even stronger and provide more confidence in the ability of the scientific community to promote good science.

The open peer-review process achieves what I believe should be the main goal of any reviewer: to help improve the scientific merit of an article.  The traditional or modern way of thinking about publishing is that it is a battle.  In this battle you have been “defeated” if you let a poor article be published so why not err on the side of caution and reject anything that seems even remotely suspect?  While I see the value in being a “gate-keeper” as a reviewer I personally feel that stopping there is lazy.  The reviewer is responsible for working with an author to improve their article and to strengthen the conclusion they have made about their hypothesis.  It would be better to put yourself on the side of the author, to have high standards for yourself, and to ask what your experience and expertise can add to this article to make it a valuable contribution to the journal.  With this in mind, open peer-review has to be the best method of fostering the author-reviewer relationship.  As a society we seem to be moving ever more and more towards a need for openness and transparency in institutions as well.  Having a clear, open review allows gives us confidence in the peer-review process and allows us to sniff out collusion or scientific misconduct.  I would encourage everyone to take a look at some articles that have been reviewed under “open peer-review” and to decide for themselves what makes the most sense.


Thank you all for reading!



  1.  https://www.timeshighereducation.com/features/peer-review-not-old-you-might-think
  2. https://publons.com/home/

Van Rooyen S. et al. “Effect of open peer review on quality of reviews and on reviewers’ recommendations: a randomized trial” BMJ 1999;318:23

Why are People “Rallying Around Science”?

Hello Everyone,

I, like many other scientists, participated in the March for Science this past month.  Today I wanted to mention briefly my reasons for participating in the March.  There are some good questions being raised in the scientific community about whether or not scientists should be involved in politics or influencing public policy.  In my personal, humble, opinion people who think that science is “above politics” are full of themselves.  We are all human beings, we all have our own goals and we want to have input on public policy because, by its nature, it affects us.  I had the great opportunity last Friday to meet with Dr. Franklin Carrero-Martinez, the Deputy Science and Technology Adviser to the Secretary of State.  Dr. Carrero is a scientist by training and one who is now heavily involved in helping the State Department determine what to do with scientific information.  This does not mean hiding any information or presenting a biased view but it does mean forming an opinion and making a decision based on a fair reading of the facts.  That’s what I was marching for, a fair reading of the facts.  In the field of public policy, opinions should not be formed and then backed up with data after the fact.  All facts should be debated and an opinion should be formed from that debate.  Of course, new data can always help us to refine or even change our opinions.  In my mind, however, the failure to form an opinion and failure to take decisive action is a failure in leadership.  So again, I’ll call on everyone to please get involved in scientific research and to think about how it affects your daily life.


Thanks for reading,